All types 8KO 4KI 1Transgenic 1Conditional 2
8 models
Model / strainTypeGene / diseaseSource
Mecp2-KO (B6.129)KOMECP2 · Rett syndromeJAX #003890Selected →
Mecp2-KO (B6.129)KO
MECP2 · Rett syndrome · JAX #003890Selected →Smn1-KI (SMA Δ7)KISMN1 · Spinal muscular atrophyJAX #005025View →
Smn1-KI (SMA Δ7)KI
SMN1 · Spinal muscular atrophy · JAX #005025View →Dmd-mdxTransgenicDMD · Duchenne muscular dystrophyJAX #001801View →
Dmd-mdxTransgenic
DMD · Duchenne muscular dystrophy · JAX #001801View →Gaa-KOKOGAA · Pompe diseaseIn-house breeding colonyView →
Gaa-KOKO
GAA · Pompe disease · In-house breeding colonyView →Rpe65-KOKORPE65 · Leber congenital amaurosisJAX #006048View →
Rpe65-KOKO
RPE65 · Leber congenital amaurosis · JAX #006048View →Mecp2-Flox (conditional)ConditionalMECP2 · Rett syndromeJAX #006847View →
Mecp2-Flox (conditional)Conditional
MECP2 · Rett syndrome · JAX #006847View →Dmd-KO (exon 51 del)KODMD · Duchenne muscular dystrophyIn-house breeding colonyView →
Dmd-KO (exon 51 del)KO
DMD · Duchenne muscular dystrophy · In-house breeding colonyView →Gaa-Flox (conditional)ConditionalGAA · Pompe diseaseCollaborator-derived colonyView →
Gaa-Flox (conditional)Conditional
GAA · Pompe disease · Collaborator-derived colonyView →Model detail
Mecp2-KO (B6.129)
KOStrain background
C57BL/6, germline knockout, hemizygous males used for study
Source
JAX #003890
Phenotype
Normal at birth; regression of motor and behavioral function from ~6 weeks, hindlimb clasping, reduced brain weight.
Phenotype figure / diagram